Autoantigen cross-reactive environmental antigen can trigger multiple sclerosis-like disease

Infection as an Environmental Trigger of Multiple Sclerosis Disease Exacerbation

Over the past several decades, significant advances have been made in identifying factors that contribute to the pathogenesis of multiple sclerosis (MS) and have culminated in the approval of some effective therapeutic strategies for disease intervention. However, the mechanisms by which environmental factors, such as infection, contribute to the pathogenesis and/or symptom exacerbation remain ...

Epstein-barr virus: environmental trigger of multiple sclerosis?

Can stress trigger Parkinson's disease?

In this manuscript we summarize the role of chronic stress as a potential trigger factor for Parkinson's disease. Underlying mechanisms and stress-induced changes to the neuronal networks have been highlighted. Examples of stress induced reversible symptoms that resemble parkinsonism in humans and in animal models raise the question whether emotional stress can cause striatal degeneration in su...

Tumor-like multiple sclerosis.

Multiple sclerosis is a chronic demyelinating disease of the central nervous system. Tumor-like manifestation of multiple sclerosis is one of the rare clinical variants and it is frequently misdiagnosed. This is a report on a 45-year-old man who presented with right-sided hemiparesis. Initial computed tomography and magnetic resonance imaging studies of the brain revealed a large hyperintense s...

CLONING AND SEQUENCING OF A MITOCHONDRIAL AUTOANTIGEN WITH IMMUNOGLOBULIN G FROM PATIENTS WITH MULTIPLE SCLEROSIS

Multiple Sclerosis (MS) is a chronic neurological disease of the central nervous system (CNS), characterised by a cellular immune response in early stages and demyelination of the CNS later. Although the cause of MS is unknown, there is much evidence that points to MS as an autoimmune disease. To test the hypotheses that an Autoantigen is involved in MS, we screened a ?gt11 human foetal spinal ...